Neo-CODA | PMID 16844102

Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.

PMID 16844102 · Relations processed 2025-10-13T15:41:19.264000

Title

Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.

Abstract

Methamphetamine (MA)-induced dopaminergic neurotoxicity is believed to be associated with the increased formation of free radicals. This study examined the effect of alpha-tocopherol (alpha-TC), a scavenger of reactive oxygen species, and deferoxamine (DFO), an iron chelator, on the MA-induced neurotoxicity. Male rats were treated with MA (10 mg/kg, every 2 h for four injections). The rat received either alpha-TC (20 mg/kg) intraperitoneally for 3 days and 30 min prior to MA administration or DFO (50 mg/kg) subcutaneously 30 min before MA administration. The concentrations of dopamine (DA), serotonin and their metabolites decreased significantly after MA administration, which was inhibited by the alpha-TC and DFO pretreatment. alpha-TC and DFO attenuated the MA-induced hyperthermia as well as the alterations in the locomotor activity. The level of lipid peroxidation was higher and the reduced glutathione concentration was lower in the MA-treated rats. These changes were significantly attenuated by alpha-TC and DFO. This suggests that alpha-TC and DFO ameliorate the MA-induced neuronal damage by decreasing the level of oxidative stress.

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gene chemical disease

Summary

Entities: 10 Relations: 29

NEGATIVE_CORRELATION: 15 POSITIVE_CORRELATION: 9 ASSOCIATION: 5

chemical (6) disease (4)

Entity Breakdown

Type	Count
chemical	6
disease	4

Normalized Entities

Entity	Type	Source	ID	Mentions	Surface forms
Dopamine	chemical	mesh	`D004298`	3	DA, dopamine
Deferoxamine	chemical	mesh	`D003676`	8	DFO, deferoxamine
Methamphetamine	chemical	mesh	`D008694`	10	MA, methamphetamine
alpha-Tocopherol	chemical	mesh	`D024502`	8	alpha-TC, alpha-tocopherol
Glutathione	chemical	mesh	`D005978`	1	glutathione
Serotonin	chemical	mesh	`D012701`	1	serotonin
Drug Fever	disease	mesh	`D000092582`	1	MA-induced hyperthermia
MPTP Poisoning	disease	mesh	`D020267`	1	dopaminergic neurotoxicity
Neurotoxicity Syndromes	disease	mesh	`D020258`	1	neurotoxicity
Oxidative Stress	disease	mesh	`D018384`	1	oxidative stress

Relations

Subject	Relation	Object
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	POSITIVE_CORRELATION	disease MPTP Poisoning mesh: `D020267` Surface: dopaminergic neurotoxicity Mentions: 1 Context The passage states that methamphetamine (MA) induces dopaminergic neurotoxicity, indicating a chemical-induced disease relationship.
chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8	NEGATIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that alpha-tocopherol (alpha-TC) pretreatment attenuated the methamphetamine-induced neurotoxicity, indicating the chemical treats/reduces the disease neurotoxicity.
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	POSITIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that "Methamphetamine (MA)-induced dopaminergic neurotoxicity," indicating the chemical methamphetamine causes the disease neurotoxicity.
chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8	NEGATIVE_CORRELATION	disease Oxidative Stress mesh: `D018384` Surface: oxidative stress Mentions: 1 Context The passage states that alpha‑tocopherol (alpha‑TC) ameliorates methamphetamine‑induced neuronal damage by decreasing the level of oxidative stress, indicating the chemical treats/reduces the disease.
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	NEGATIVE_CORRELATION	disease Drug Fever mesh: `D000092582` Surface: MA-induced hyperthermia Mentions: 1 Context The passage states that deferoxamine (DFO) attenuated the MA-induced hyperthermia, indicating the chemical reduces the disease (Drug Fever).
chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8	NEGATIVE_CORRELATION	disease Drug Fever mesh: `D000092582` Surface: MA-induced hyperthermia Mentions: 1 Context The passage states that alpha-TC pretreatment attenuated the MA-induced hyperthermia, indicating the chemical reduces the disease.
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	POSITIVE_CORRELATION	disease Drug Fever mesh: `D000092582` Surface: MA-induced hyperthermia Mentions: 1 Context The passage states that methamphetamine (MA) induces hyperthermia (drug fever), indicating a chemical-induced disease relationship.
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	NEGATIVE_CORRELATION	disease MPTP Poisoning mesh: `D020267` Surface: dopaminergic neurotoxicity Mentions: 1 Context The passage states that dopamine concentrations decreased significantly after methamphetamine-induced dopaminergic neurotoxicity, indicating the disease causes a decrease of the chemical level.
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	POSITIVE_CORRELATION	chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1 Context The passage states that the reduced glutathione concentration, which was lowered by methamphetamine, was significantly attenuated by deferoxamine (DFO), indicating DFO prevents the decrease and thus positively correlates with glutathione levels.
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	NEGATIVE_CORRELATION	chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8 Context The passage states that alpha-tocopherol (alpha-TC) pretreatment inhibited the decreases in neurotransmitter levels and attenuated MA-induced hyperthermia and neurotoxicity, indicating alpha-TC reduces the effects of methamphetamine.
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	ASSOCIATION	chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10 Context The passage states that dopamine concentrations decreased significantly after methamphetamine administration, indicating an explicit effect between the two chemicals.
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	NEGATIVE_CORRELATION	chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10 Context The passage states that deferoxamine (DFO) pretreatment inhibited the changes caused by methamphetamine (MA) and attenuated MA-induced neurotoxicity, indicating DFO decreases the effect of MA.
chemical Serotonin mesh: `D012701` Surface: serotonin Mentions: 1	NEGATIVE_CORRELATION	disease MPTP Poisoning mesh: `D020267` Surface: dopaminergic neurotoxicity Mentions: 1 Context The passage states that serotonin concentrations decreased significantly after methamphetamine-induced dopaminergic neurotoxicity, indicating the disease causes a decrease of the chemical.
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	NEGATIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that deferoxamine (DFO) pretreatment attenuated the methamphetamine-induced neurotoxicity, indicating DFO treats/ reduces the neurotoxicity disease.
chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1	NEGATIVE_CORRELATION	disease Oxidative Stress mesh: `D018384` Surface: oxidative stress Mentions: 1 Context The passage states that the reduced glutathione concentration was lower in the methamphetamine‑treated rats, which exhibit oxidative stress, indicating the disease (oxidative stress) causes a decrease of the chemical (glutathione).
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	POSITIVE_CORRELATION	disease Oxidative Stress mesh: `D018384` Surface: oxidative stress Mentions: 1 Context The passage states that methamphetamine-induced neurotoxicity is associated with increased formation of free radicals and that lipid peroxidation levels were higher in MA‑treated rats, indicating methamphetamine induces oxidative stress.
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	ASSOCIATION	chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8 Context The passage states that the decrease in dopamine caused by methamphetamine was inhibited by alpha‑tocopherol pretreatment, indicating an association between the two chemicals.
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	POSITIVE_CORRELATION	chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8 Context The passage states that the decrease in dopamine caused by methamphetamine was inhibited by deferoxamine pretreatment, indicating that deferoxamine positively affects dopamine levels.
chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8	POSITIVE_CORRELATION	chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1 Context The passage states that reduced glutathione levels caused by methamphetamine were significantly attenuated by alpha‑TC, indicating that alpha‑tocopherol increased glutathione concentration.
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	NEGATIVE_CORRELATION	chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1 Context The passage states that the reduced glutathione concentration was lower in the MA‑treated rats, indicating that methamphetamine decreases glutathione levels.
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	ASSOCIATION	chemical Serotonin mesh: `D012701` Surface: serotonin Mentions: 1 Context The passage states that the decrease in serotonin caused by methamphetamine was inhibited by deferoxamine pretreatment, indicating an association between deferoxamine and serotonin levels.
chemical Serotonin mesh: `D012701` Surface: serotonin Mentions: 1	NEGATIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that serotonin levels decreased significantly after methamphetamine administration, which induces neurotoxicity, indicating the disease (neurotoxicity) causes a decrease of the chemical (serotonin).
chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1	NEGATIVE_CORRELATION	disease MPTP Poisoning mesh: `D020267` Surface: dopaminergic neurotoxicity Mentions: 1 Context The passage states that dopaminergic neurotoxicity (MPTP poisoning) caused a lower reduced glutathione concentration, matching the guideline for Disease causing decrease of the chemical level (Negative_Correlation).
chemical Deferoxamine mesh: `D003676` Surface: DFO, deferoxamine Mentions: 8	NEGATIVE_CORRELATION	disease Oxidative Stress mesh: `D018384` Surface: oxidative stress Mentions: 1 Context The text states that deferoxamine (DFO) pretreatment attenuated MA-induced changes and "decreasing the level of oxidative stress," indicating DFO reduces oxidative stress, i.e., the chemical treats the disease.
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	POSITIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that dopamine concentrations decreased significantly after methamphetamine-induced neurotoxicity, indicating the disease (neurotoxicity) causes a decrease of the chemical (dopamine), which matches the Positive_Correlation definition.
chemical Methamphetamine mesh: `D008694` Surface: MA, methamphetamine Mentions: 10	ASSOCIATION	chemical Serotonin mesh: `D012701` Surface: serotonin Mentions: 1 Context The passage states that serotonin concentrations decreased significantly after methamphetamine (MA) administration, indicating an explicit relationship between the two chemicals.
chemical alpha-Tocopherol mesh: `D024502` Surface: alpha-TC, alpha-tocopherol Mentions: 8	POSITIVE_CORRELATION	chemical Serotonin mesh: `D012701` Surface: serotonin Mentions: 1 Context The passage states that the MA-induced decrease in serotonin was inhibited by alpha-TC, indicating that alpha-tocopherol increased (or prevented the decrease of) serotonin levels.
chemical Glutathione mesh: `D005978` Surface: glutathione Mentions: 1	NEGATIVE_CORRELATION	disease Neurotoxicity Syndromes mesh: `D020258` Surface: neurotoxicity Mentions: 1 Context The passage states that reduced glutathione concentration was lower in the methamphetamine‑induced neurotoxicity, indicating the disease (neurotoxicity) causes a decrease of the chemical (glutathione).
chemical Dopamine mesh: `D004298` Surface: DA, dopamine Mentions: 3	ASSOCIATION	disease Drug Fever mesh: `D000092582` Surface: MA-induced hyperthermia Mentions: 1 Context The passage reports that dopamine levels decrease after methamphetamine administration and that methamphetamine also induces hyperthermia (drug fever), with both effects being attenuated by alpha‑tocopherol and deferoxamine, indicating an association between dopamine (chemical) and the disease hyperthermia.